Lariam works by targeting the malaria parasite in the bloodstream, preventing it from multiplying and causing infection.

• Interferes with the growth and survival of malaria parasites
• Helps prevent malaria when taken regularly before and during travel
• Can be used to treat malaria infections when prescribed

For prevention, it is important to begin treatment well before travel to assess tolerance.

• Active ingredient: Mefloquine
• Pharmaceutical form: Tablets
• Administration route: Oral
• Prescription status: Prescription-only medicine (Rx)

Indications

Lariam is indicated for the prevention and treatment of malaria caused by susceptible strains of Plasmodium, as determined by a healthcare professional.

Dosage & use

• Dosage depends on body weight, age, and whether used for prevention or treatment
• For prevention, tablets are usually taken once weekly
• It is recommended to start at least 2–3 weeks before entering a malaria area
• Continue use during travel and for several weeks after leaving the risk area

Warnings

• Neuropsychiatric effects: Lariam may cause anxiety, mood changes, depression, sleep disturbances, or dizziness
• Not suitable for people with a history of depression, anxiety disorders, psychosis, epilepsy, or seizures
• Stop use and seek medical advice if severe side effects occur
• May impair concentration or coordination; caution with driving or operating machinery

What is Lariam used for?
Lariam is used to prevent malaria in travellers and to treat malaria infections when prescribed.

Why must Lariam be started weeks before travel?
Starting early allows time to assess tolerance and detect side effects before entering a malaria-risk area.

Is Lariam safe for everyone?
No. Lariam is not suitable for people with certain neurological or psychiatric conditions. A medical assessment is required.

What should I do if I experience mood or sleep changes?
Stop taking Lariam and seek medical advice immediately if you experience significant mood changes, anxiety, depression, or sleep disturbances.

Do I still need mosquito protection?
Yes. Antimalarial tablets reduce risk but must always be combined with mosquito avoidance measures.

Can Lariam be used during pregnancy?
In some cases, Lariam may be prescribed during pregnancy if advised by a healthcare professional.